193 Gedanken zu „List of PML diseases under Tysabri (May 2013)“

1. Ernest Kaiser 19. April 2013 um 17:43

   In my opinion, the rate of PML infections associated with Tysabri infusions is well within the possible error rate of misidentifying MS, which is extremely similar to PML. IF a patient has a low level, active PML infection, the symptoms are so similar to MS that some misdiagnosis are inevitable. PML to a normal immune system is best handled by the immune system. However, if it is thought to be MS and it is treated with Tysabri, the results are likely to be disastrous. Tysabri subdues the single most important immune body that combats the JC virus. As my friend Mike B. believes, there has been no proven case of MS and PML in the same patient at the same time. That concept makes sense since in one case, the cause is thought to be overactive immune cells, and the other is caused by that same immune agent not being able to suppress a virus. These are contradictory conditions, unlikely if not unable to exist at the same time.
2. Michele Findlay 14. Mai 2013 um 11:44

   Wanted to say how much I appreciate the updates we receive regarding the effects of Tysabri and PML.
3. Alexander Otto Artikelautor17. Mai 2013 um 08:40

   Bad news again:

   As of May 6, 2013, there have been 359 confirmed cases of PML worldwide (123 in the US). 83 of 359 (23%) of the patients with PML have died.

   As of March 31, 2013, approximately 115,365 patients have received natalizumab in the post-marketing setting worldwide.